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doxorubicin hydrochloride/steroidsbio@chembj.com
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| Post Date: | Jun 26,2017 |
| Expiry Date: | Jun 26,2018 |
| Detailed Description: |
Cas No. :25316-40-9
Quantity: 10g Price:1 USD Metric Tons Payment Method: Western Union,Money Gram,T/T,Bitcoin Product name：doxorubicin hydrochloride，Doxorubicin HCL，DOX CAS: 25316-40-9 EINECS: 246-818-3 MF: C27H30ClNO11 MW: 579.9802 Synonym: DOX, Hydroxydaunorubicin hydrochloride Antineoplastic antibiotic obtained from Streptomyces peucetius. Doxorubicin Hydrochloride is a hydroxy derivative of DAUNORUBICIN. Usage Doxorubicin Hydrochloride is the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects. |
| CAS Registry Number: | 25316-40-9 |
| Synonyms: | ;Doxorubicin, HCl;(8s-cis)-10-((3-amino-2,3,6-trideoxy-alpha-l-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxynaphthacene-5,12-dione hydrochloride;(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside hydrochloride (1:1);(1S,3S)-3,5,12-trihydroxy-3-(hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside hydrochloride (1:1);Doxorubicin HCL;Doxourbicin HCl; |
| Molecular Formula: | C27H30ClNO11 |
| Molecular Weight: | 579.9802 |
| Molecular Structure: | 
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| Company: | Wuhan Hengwo Technology co.,Ltd [ China ] |
| Contact: | jerry |
| Tel: | +86-000-123456 |
| Fax: | |
| Email: | steroidsbio@chembj.com |
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